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Clinical data
Trade namesClomid, others [1]
AHFS/Drugs.comMonograph
Pregnancy categoryAU: B3 US: X (Contraindicated)
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ATC codeG03GB02 ( WHO )
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MetabolismLiver (with enterohepatic circulation)
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Comment №1 about product

Outcomes of long-term testosterone replacement in older hypogonadal males: The specific mechanism may be an age-related increased sensitivity of the hypothalamic-pituitary unit to the negative feedback effect of testosterone Winters et al


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The hypothalamus stimulates the growth of follicles in the ovary - say, let us grow, produce estrogen, and then we've got a deficit! In older men, the decline in circulating testosterone also correlates with changes in the testes, specifically a decline in Leydig cell number Neaves et al , development of vacuolizations and lipofuscin within the Leydig cells, and decreased Leydig cell secretion of testosterone in response to provocative stimulation with human chorionic gonadotrophin Harman and Tsitouras


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